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KMID : 1134820000290010093
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Journal of the Korean Society of Food Science and Nutrition
2000 Volume.29 No. 1 p.93 ~ p.98
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The Effects of Shi - Quan - Dai - Bu - Tang and Its Ingredients on the Survival of Jejunal Crypt Cells and Hematopoietic Cells in Irradiated Mice
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Jo Sung-Kee
Yu Young-Bub
Oh Heon
Kim Se-Ra
Kim Seong-Ho
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Abstract
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We performed this study to determine the radioprotective effects of Shi-Quan-Dai-Bu-Tang, as a prescription of traditional Oriental medicine, and its major ingredients. The jejunal crypt survival, endogenous spleen colony formation, and apoptosis in jejunal crypt cells were investigated in mice irradiated with high and low dose of γ-rays. The administration of danggui, baishaoyao, rensan, gancao or bai - fuling before irradiation protected the jejunal crypts (p<0.005). Shoudehuang, danggui, baishaoyao, rensan and huangqui increased the formation of endogenous spleen colony (p<0.05). Chuanxiong, baishaoyao, rensan and baifuling reduced the frequency of radiation-induced apoptosis (p<0.05). The results indicated that the extracts of danggui, baishaoyao, rensan and baifuling may have radioprotective effects in mice irradiated with high and low dose of γ-rays. The radioprotective effect of the prescription, Shi-Quan-Da-Bu-Tang, was not significant.
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KEYWORD
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Shi-Qaun-Da-Bu-Tang, radioprotective, jejunal crypt, spleen
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